1-(2-Methoxyphenyl)piperazine → HCID 21551664, compound

HRID 268400Notes

Reaction equation

HRID 268400 reaction equation
[C:1]1([O:11][CH2:12][CH:13]([OH:29])[CH2:14][N:15]2[CH2:20][CH2:19][N:18](C3C=CC(OC)=CC=3)[CH2:17][CH2:16]2)[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:30]1([O:40][CH2:41]C2OC2)[C:39]2CCCC[C:34]=2[CH:33]=[CH:32][CH:31]=1.COC1C=CC=CC=1N1CCNCC1>>[C:1]1([O:11][CH2:12][CH:13]([OH:29])[CH2:14][N:15]2[CH2:16][CH2:17][N:18]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:39][C:30]=3[O:40][CH3:41])[CH2:19][CH2:20]2)[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 12445765HCID 12445765, compoundHCID 21551674HCID 21551674, compound

Product 1

HCID 21551664HCID 21551664, compound

Procedure

1-[3-(5,6,7,8-tetrahydronaphth-1-yloxy)-2-hydroxyprop-1-yl]-4-(4-methoxyphenyl)-piperazine from 1-(5,6,7,8-tetrahydronaphth-1-yloxy)-2,3-epoxypropane and 1-(4-(methoxyphenyl)-piperazine; yield 72% of theory; m.p. 83°-84°C. (recrystallized from isopropanol); m.p. of the dihydrochloride 230°-231°C. (decomp.).

Workup

  1. customm.p. 83°-84°C. (recrystallized from isopropanol)

Sources & evidence

ORD record
ord-21af01655b1b4954bce57fe6da232c86
Source dataset
uspto-grants-1976_03
Patent number
US03947446

Reaction notes

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