HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → (+/-)-6-Acetoxy-2,5,7,8-tetramethylchroman-2-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 6-Acetoxy-2,5,7,8-tetramethyl-2-cyanochromane | HCID 14415675 | — |
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Product | (+/-)-6-Acetoxy-2,5,7,8-tetramethylchroman-2-carboxaldehyde | HCID 15818868 | — |
Reaction Steps
(±)-6-acetoxy-2-cyano-2,5,7,8-tetramethylchroman was reduced with diisobutylaluminum hydride as described in Example 101, with tetrahydrofuran as reaction solvent. TLC of the crude product indicated that it was partially deacetylated. The material was thus reacetylated by the process described in Example 2 to give (±)-6-acetoxy-2,5,7,8-tetramethylchroman-2-carboxaldehyde as a white solid, m.p. 88°-90°, from 30°-60° petroleum ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947473 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-efaa266f25fb4649907605182e398c8f |
| Source note | uspto-grants-1976_03 |