5-Hydroxy-7-[5-(4-Fluorophenyl)-2-Pentyl]-4-(4-Pyridyl)Coumarin → HCID 23878078, compound

HRID 268445Notes

Reaction equation

HRID 268445 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([CH:12]([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[CH3:13])[CH:9]=[C:8]2[C:3]=1[C:4]([C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1)=[CH:5][C:6](=[O:24])[O:7]2>C(O)C>[OH:1][C:2]1[CH:11]=[C:10]([CH:12]([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[CH3:13])[CH:9]=[C:8]2[C:3]=1[CH:4]([C:25]1[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=1)[CH2:5][C:6](=[O:24])[O:7]2

Participants

3

Reactant 1

HCID 239388075-Hydroxy-7-[5-(4-Fluorophenyl)-2-Pentyl]-4-(4-Pyridyl)Coumarin

Product 1

HCID 23878078HCID 23878078, compound

Reagents, catalysts & solvents 1

HCID 702EthanolCatalyst

Procedure

The coumarin of Example 2 (2.2 g) was hydrogenated in ethanol using 5% palladium on carbon as a catalyst. The resulting oil was purified on a Florisil column, eluting with chloroform to give the desired product.

Workup

  1. customThe resulting oil was purified on a Florisil column
  2. washeluting with chloroform

Sources & evidence

ORD record
ord-92d95fcff0494625b5e9bbc24178a3e4
Source dataset
uspto-grants-1976_03
Patent number
US03947462

Reaction notes

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