HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorogramine → 3-(2'-Methyl-2'-nitrobutyl)-5-fluoro-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorogramine | HCID 9576 | — |
| Reactant | 2-Nitrobutane | HCID 11749 | — |
| Product | 3-(2'-Methyl-2'-nitrobutyl)-5-fluoro-indole | HCID 21552250 | — |
Reaction Steps
The procedure described in Example 3 applied to 5-fluorogramine and 2-nitrobutane yielded the intermediate product 3-(2'-methyl-2'-nitrobutyl)-5-fluoro-indole. Melting point 71°-72°C. (from benzine). Catalytic reduction thereof yielded 3-(2'-methyl-2'-aminobutyl)-5-fluoro-indole; melting point of the hydrochloride salt 248°-250°C. (from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947584 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-09f55a5d4cd54701a5096c862df97f83 |
| Source note | uspto-grants-1976_03 |