Methyl iodide → HCID 21552248, compound

Participants

Reaction Steps

If the 3-(2'-methyl-2'-nitrobutyl)-5-methoxy-indole obtained as intermediate product in Example 2 is methylated by the procedure described in Example 4 (or by means of sodium hydride and methyl iodide in hexamethyl phosphoric acid triamide), 1-methyl-3-(2'-methyl-2'-nitrobutyl)-5-methoxy-indole is obtained and melts at 95°-96°C. after crystallisation from acetone/water and distillation. Catalytic reduction thereof yields 1-methyl-3-(2'-methyl-2'-aminobutyl)-5-methoxy-indole. Melting point of the benzoic acid salt 179.5°-184°C. (insoluble in ether).

Provenance & Evidence