反应详情

To a solution of 5.1 gm. of 2-(3-fluoro-4-methyl-phenyl) benzoxazole in 60 ml. of carbon tetrachloride is added 6.23 gm. N-bromosuccinimide and 100 mg. of dibenzoyl peroxide. The reaction mixture is refluxed for 6 hours, filtered to remove succinimide and the filtrate concentrated to dryness. The residue is chromatographed on 500 gm. of silica gel. Elution with 1% ether in petroleum ether gives 2-(4-bromomethyl-3-fluorophenyl)benzoxazole, m.p. 150°-152°C.

1. temperatureThe reaction mixture is refluxed for 6 hours
2. filtrationfiltered
3. customto remove succinimide
4. concentrationthe filtrate concentrated to dryness
5. customThe residue is chromatographed on 500 gm
6. washElution with 1% ether in petroleum ether