反应详情

To a solution of 0.6 gm. of sodium cyanide in 25 ml. of dimethyl sulfoxide preheated to 65°-70°C. is slowly added 2.5 gm. of 2-(4-bromomethyl-3-fluorophenyl)-benzoxazole. The reaction mixture is heated at 60°-70°C. for 1 hour, then cooled and poured into water. The resulting precipitate is filtered off and chromatographed on 300 gm. of silica gel. Elution with methylene chloride gives 4-(benzoxazol-2-yl)-2-fluorophenylacetonitrile.

1. custompreheated to 65°-70°C.
2. temperatureThe reaction mixture is heated at 60°-70°C. for 1 hour
3. temperaturecooled
4. filtrationThe resulting precipitate is filtered off
5. customchromatographed on 300 gm
6. washElution with methylene chloride