4-Ethyl-2-fluoro-N-(2-hydroxyphenyl)benzamide → 2-(4-Ethyl-2-fluorophenyl)-1,3-benzoxazole

Participants

Reaction Steps

4-Ethyl-2-fluoro-2'-hydroxybenzanilide (29.0 gm.) is heated for 40 minutes in a Wood's metal bath at 240°C. The reaction mixture is then cooled, taken up in chloroform and the chloroform solution treated with carbon, dried over magnesium sulfate and concentrated in vacuo to give 2-(4-ethyl-2-fluorophenyl)benzoxazole.

Provenance & Evidence