HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Ethyl 2-methylacetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Ethyl benzoylacetate | HCID 7170 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | Ethyl 2-oxocyclopentanecarboxylate | HCID 69136 | — |
| Reactant | Ethyl 2-methyl-beta-oxobenzenepropanoate | HCID 2760276 | — |
| Product | Ethyl 2-methylacetoacetate | HCID 701 | — |
| Product | Ethyl 1-methyl-2-oxocyclopentane-1-carboxylate | HCID 227353 | — |
| Product | Ethyl 2,2-dimethylbenzoylacetate | HCID 68118422 | — |
Reaction Steps
When the thallous salts of ethyl acetoacetate, 2-carbethoxycyclopentanone, ethyl benzoylacetate, and ethyl 2-methylbenzoylacetate, prepared according to Example 1, are refluxed with methyl iodide as described in Example 1 for periods of about 4, 9, 4, and 14 hours, respectively, ethyl 2-methylacetoacetate (b.p. 82°/25 mm.), 2-methyl- 2-carbethoxy-cyclopentanone (b.p. 124°-126°/35 mm.), ethyl 2-methylbenzoyl acetate (b.p. 96°-97°/0.25 mm.), and ethyl 2,2-dimethylbenzoyl-acetate (b.p. 98°-100°/0.35 mm.), respectively, are obtained in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947488 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-25422b156e2344fcb6334b2a06b491e6 |
| Source note | uspto-grants-1976_03 |