Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]urea

HRID 26852Notes

Reaction equation

HRID 26852 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:15]

Participants

3

Reactant 2

HCID 12228Methyl IsocyanateHCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 20557658N-Methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]urea

Procedure

By the procedure of Example 24, N-(2-pyrimidylmethyl)ethylenediamine is reacted with methyl isocyanate to give, after concentrating and separating the residue by column chromatography, the title compound.

Workup

  1. customto give
  2. concentrationafter concentrating
  3. customseparating the residue by column chromatography

Sources & evidence

ORD record
ord-c01fe4e9ffaf4cbeb3133c40c84c98c9
Source dataset
uspto-grants-1979_04
Patent number
US04151288

Reaction notes

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