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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268536Generated: November 1, 2026

Hydrazine hydrate (1:1) → 8-Nitro-1-(aminomethyl)-6-(o-chlorophenyl)4H-s-triazolo[4,3-a][1,4]benzodiazepine

https://huagongshe.com/reaction/268536

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrazine hydrate (1:1)HCID 24654—
Reactant2'-chloro-5-nitro-2-[3,5-bis(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenoneHCID 21551881—
SolventEthanolHCID 702—
Product8-Nitro-1-(aminomethyl)-6-(o-chlorophenyl)4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 21551887—

Reaction Steps

In the manner given in Example 22, 5-nitro-2'-chloro-2-[3,5-bis(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is heated with hydrazine hydrate to give 8-nitro-1-(aminomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]enzodiazepine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03947466
Source datasetuspto-grants-1976_03
ORD IDord-45cd83e91c5d47209b97ebcd04ae7f8b
Source noteuspto-grants-1976_03