HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-[(dimethylamino)methyl]-8-nitro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 8-Nitro-1-(aminomethyl)-6-(o-chlorophenyl)4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 21551887 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-[(dimethylamino)methyl]-8-nitro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20291845 | — |
Reaction Steps
In the manner given in Example 23 a solution of 8-nitro-1-(aminomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in acetonitrile is treated with formalin, sodium cyanoborohydride and propionic acid to give 8-nitro-1-[ (dimethylamino)methyl]-6-(o-chlorophenyl)4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947466 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-a25171d2c1f944f6a9f76a3e5d9368cc |
| Source note | uspto-grants-1976_03 |