HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 8-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Acetaldehyde | HCID 177 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Desmethyladinazolam | HCID 12611937 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 12612357 | — |
Reaction Steps
In the manner given in Example 23, a solution of 8-chloro-1-(aminomethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in acetonitrile is treated with acetaldehyde, sodium cyanoborohidride and acetic acid to give 8-chloro-1-[(diethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947466 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-93c846da813c4b86b1da0c152488a6d1 |
| Source note | uspto-grants-1976_03 |