Methyl Isocyanate → N-Methyl-N'-[2-(2-pyrazinylmethylamino)ethyl]urea

HRID 26856Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][NH:8][CH2:9][CH2:10][NH2:11].[CH3:12][N:13]=[C:14]=[O:15]>>[CH3:12][NH:13][C:14]([NH:11][CH2:10][CH2:9][NH:8][CH2:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:15]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 13910894N-(pyrazinylmethyl)ethylenediamine

Product 1

HCID 20557893N-Methyl-N'-[2-(2-pyrazinylmethylamino)ethyl]urea

Procedure

Reacting N-(2-pyrazinylmethyl)ethylenediamine with methyl isocyanate by the procedure of Example 24, then concentrating and separating the residue by column chromatography gives the title compound.

Workup

concentrationconcentrating
customseparating the residue by column chromatography

Sources & evidence

ORD record: ord-bbecb49f34aa4c5b85a4a052fb01ae10
Source dataset: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04151288

Reaction notes

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