HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268566Generated: October 26, 2026
Triethylamine → 4-(4-Nitro-2-methylphenylamino)butan-2-ol
https://huagongshe.com/reaction/268566
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Benzene, 1-fluoro-2-methyl-4-nitro- | HCID 68001 | — |
| Reactant | 2-Butanol, 4-amino- | HCID 170254 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(4-Nitro-2-methylphenylamino)butan-2-ol | HCID 23104308 | 82.3% |
Reaction Steps
2 g of 2-fluoro-5-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.38 g of 4-amino-2-butanol and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 2.38 g of 4-(4-nitro-2-methylphenylamino)butan-2-ol (27) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07445645B2 |
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| Source dataset | uspto-grants-2008_11 |
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| ORD ID | ord-4da51da5a808409a865b320d3e83debe |
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| Source note | uspto-grants-2008_11 |
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