反应详情

A solution of 1a (0.80 g, 2.06 mmole) in 40% trifluoroacetic acid/dichloromethane (15 mL) was stirred at room temperature for 4 h. The solvent was removed by rotary evaporation, and the resulting organic residue was carefully partitioned between dichloromethane and a saturated solution of sodium bicarbonate (30 mL each). The organic extract was dried over anhydrous sodium sufate, filtered, and concentrated to give 2a as a light brown oil. This amine was used without further purification.

1. customThe solvent was removed by rotary evaporation
2. customthe resulting organic residue was carefully partitioned between dichloromethane
3. extractionThe organic extract
4. dry with materialwas dried over anhydrous sodium sufate
5. filtrationfiltered
6. concentrationconcentrated