1,4-Difluoro-2-isocyanatobenzene → N-(1-Benzyl-pyrrolidin-3-(R)-yl)-2-(S)-[3-(2,5-difluoro-phenyl)-ureido]-3,3-dimethyl-butyramide

Participants

Role	Name	HCID	Charge
Reactant	1,4-Difluoro-2-isocyanatobenzene	HCID 2733266	—
Reactant	2-(S)-Amino-N-(1-benzyl-pyrrolidin-3-(R)-yl)-3,3-dimethyl-butyramide	HCID 21062336	—
Product	N-(1-Benzyl-pyrrolidin-3-(R)-yl)-2-(S)-[3-(2,5-difluoro-phenyl)-ureido]-3,3-dimethyl-butyramide	HCID 10160714	—

Compound 3d was prepared from 2,5-difluorophenyl isocyanate and compound 2a using the method described in Example 9. MS (EI)=444 (M+).