4-Fluorophenyl isocyanate → HCID 10158724, compound

HRID 268614Notes

Reaction equation

HRID 268614 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][CH:3]=1.[NH2:11][CH:12]([CH:28]([CH3:30])[CH3:29])[C:13]([N:15]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])=[O:14]>>[CH2:21]([N:15]([CH2:16][CH2:17][N:18]([CH3:19])[CH3:20])[C:13](=[O:14])[C@@H:12]([NH:11][C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)=[O:10])[CH:28]([CH3:29])[CH3:30])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 21938687HCID 21938687, compound

Product 1

HCID 10158724HCID 10158724, compound

Procedure

Compound 14b was prepared from 4-fluorophenyl isocyanate and compound 13, using the method described in Example 22. MS (EI)=414 (M+).

Sources & evidence

ORD record
ord-87651b05e3004c198b50af48b30cf257
Source dataset
uspto-grants-2008_11
Patent number
US07446115B2

Reaction notes

Loading…