Phosphorus oxide (P4O10) → HCID 69311331, compound

Participants

Reaction Steps

The product of Example 1 Step 2 (450 mg, 0.96 mmol) was added to a stirred suspension of phosphorus pentoxide (400 mg) in dry methane sulphonic acid (4ml). After stirring at room temperature for 1 hour, the reaction mixture was cautiously poured into a stirred solution of saturated aqueous sodium hydrogen carbonate. The mixture was extracted with ethyl acetate and the organic phase washed with water and brine, dried and concentrated in vacuo to give the title compound (400 mg, 93%); MS(ES+) m/e 449,451 [M+H]+.

Provenance & Evidence