Ammonium Acetate → HCID 44535824, compound

Participants

Reaction Steps

A solution of the product of Example 1 Step 2 (420 mg, 0.9 mmol) and ammonium acetate (750 mg, 9.7 mmol) in glacial acetic acid (15 ml) was heated under reflux for 16 hours. After cooling to room temperature, the reaction mixture was concentrated and aqueous sodium hydrogen carbonate solution was added. The mixture was extracted with chloroform and the organic phase washed with water and brine, dried and concentrated in vacuo to give the title compound; MS(ES+) m/e 448,450 [+H]+.

Provenance & Evidence