HCID 68797947, compound → HCID 68797312, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-{2-(4-fluoro-phenyl)-4-isopropyl-5-[methyl-(2-methyl-benzyl)-carbamoyl]-2H-pyrazol-3-yl}-3,5-dihydroxy-hept-6-enoic acid methyl ester (1.190 g, 2.21 mmol) in MeOH (50 ml) was added Pd—C (0.1 g). The reaction vessel was evacuated, flushed with nitrogen and then filled with hydrogen (via balloon). Reaction was stirred at 25° C. for 4 hrs. Reaction was then flushed with nitrogen and filtered through a pad of celite. The filtrate was concentrated and purified by column chromatography (30-40% EtOAc/Hex) to afford 7-{2-(4-fluoro-phenyl)-4-isopropyl-5-[methyl-(2-methyl-benzyl)-carbamoyl]-2H-pyrazol-3-yl}-3,5-dihydroxy-heptanoic acid methyl ester (0.792 g, 66%): MS(APCI+) 540.2 m/z (M+H).

Provenance & Evidence