反应详情

To a solution of 2-(5-bromo-7-ethyl-1H-indol-3-yl)-ethanol in dichloromethane at room temperature under nitrogen was added boron trifluoride diethyl etherate (0.809 g, 5.7 mmol), followed by ethyl propionylacetate (1.038 g, 7.2 mmol). The reaction mixture was stirred at room temperature for 5 hours. It was quenched with saturated sodium bicarbonate solution and extracted with dichloromethane. The extract was dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, 15-20% ethyl acetate/hexane) to give the title compound (0.994 g, 53% yield). ES-MS (m/z) 394 [M+1]+, 392 [M−1]−.

1. customIt was quenched with saturated sodium bicarbonate solution
2. extractionextracted with dichloromethane
3. dry with materialThe extract was dried over magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe crude product was purified by column chromatography (silica gel, 15-20% ethyl acetate/hexane)