HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(3-Piperidin-1-yl-propoxy)-2-trifluoromethyl-benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(3-Piperidin-1-yl-propoxy)-2-trifluoromethyl-benzoic acid | HCID 17986318 | — |
| Product | 4-(3-Piperidin-1-yl-propoxy)-2-trifluoromethyl-benzoyl chloride | HCID 17986255 | — |
Reaction Steps
4-(3-Piperidin-1-yl-propoxy)-2-trifluoromethyl-benzoic acid (D5) (0.9 g) was heated at reflux in thionyl chloride (20 ml) for 2 h. The reaction mixture was evaporated to a minimum then co-evaporated with DCM (3×) to give the title compound (D6) as a white solid (1.0 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446103B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-54dc54d50e2942f4a9bfbaceef46e2b1 |
| Source note | uspto-grants-2008_11 |