HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-Cyanoisoindoline trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 5-cyano-1,3-dihydro-2H-isoindole-2-carboxylate | HCID 18630967 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Cyanoisoindoline trifluoroacetate | HCID 17986279 | — |
Reaction Steps
A solution of N-t-butoxycarbonyl-5-cyanoisoindoline (D15) (130 mg) in DCM (3 ml) at rt was treated with TFA (1 ml) and after 1 h it was evaporated. The residue was re-evaporated from MeOH/toluene to give the title compound (D16) (140 mg). 1H NMR δ (CDCl3): 7.70 (2H, m), 7.50 (1H, m), 4.75 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446103B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-23a5ec05c1184be59fb21a0ec0c3e633 |
| Source note | uspto-grants-2008_11 |