化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → Trifluoroacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | tert-Butyl 4-(4-cyanophenoxy)piperidine-1-carboxylate | HCID 23019443 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 4-(4-Piperidinyloxy)benzonitrile trifluoroacetate | HCID 17986319 | — |
反応手順
4-[(1-tert-Butoxycarbonyl-4-piperidinyl)oxy]benzonitrile (D21) (6.83 g) was dissolved in DCM (30 ml) and TFA (30 ml) was added. The reaction was stirred at rt for 1 h and then evaporated to give the title compound (D22) as a yellow oil (7.15 g—TFA salt plus 1.3 equivalents of TFA).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07446103B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-3fd73069052141f396a29673fdef961f |
| 出典メモ | uspto-grants-2008_11 |