2,3,4,5-Tetrahydro-1H-benzo(d)azepine → N-[4-(3-Piperidin-1-ylpropoxy)benzoyl]-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Participants

Reaction Steps

The title compound was prepared from 4-(3-piperidin-1-ylpropoxy)benzoyl chloride hydrochloride (D3) (0.20 g) and 2,3,4,5-tetrahydro-1H-3-benzazepine (WO00/21951) (0.89 g) using the procedure described for Example 1 and isolated as a white solid (0.16 g). MS electrospray (+ion) 393 (MH+). 1H NMR δ (DMSO-d6): 9.68 (1H, s), 7.34 (2H, d, J=6.8 Hz), 7.14 (4H, m), 7.00 (2H, d, J=6.8 Hz), 4.10 (2H, t, J=5.9 Hz), 3.81-3.45 (6H, m), 3.17 (2H, m), 2.90 (6H, m), 2.17 (2H, m), 1.83-1.37 (6H, m).

Provenance & Evidence