7-Methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine → N-[4-(3-Piperidin-1-yl propoxy)benzoyl]-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride

Participants

Reaction Steps

The title compound was prepared from 4-(3-piperidin-1-ylpropoxy)benzoyl chloride hydrochloride (D3) (0.20 g) and 7-methanesulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (WO00/21951) (0.17 g) using the procedure described for Example 1 and isolated as a white solid (0.24 g). MS electrospray (+ion) 471 (MH+). 1H NMR δ (DMSO-d6): 9.83 (1H, s), 7.71 (2H, m), 7.44 (1H, s), 7.35 (2H, d, J=8.5 Hz ), 7.01 (2H, d, J=8.6 Hz), 4.11 (2H, t, J=5.9 Hz), 3.71-3.45 (6H, m), 3.18 (6H, m), 3.05 (3H, s) 2.87 (2H, m), 2.20 (2H, m), 1.83-1.37 (6H, m).

Provenance & Evidence