3-(1H-Indol-6-yl)-3-(2-methoxy-phenyl)-N-methyl-propionamide → HCID 59831641, compound

HRID 268783Notes

Reaction equation

HRID 268783 reaction equation
C[O:2][C:3](=O)[CH2:4][CH:5]([C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[CH:18][NH:19]2)=[CH:15][CH:14]=1)[C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1.[NH:23]1C2C(=CC=C(C(C3C=CC=CC=3OC)CC(NC)=O)C=2)C=[CH:24]1>>[NH:19]1[C:20]2[C:16](=[CH:15][CH:14]=[C:13]([CH:5]([C:6]3[CH:7]=[CH:8][C:9]([Cl:12])=[CH:10][CH:11]=3)[CH2:4][C:3]([NH:23][CH3:24])=[O:2])[CH:21]=2)[CH:17]=[CH:18]1

Participants

3

Reactant 2

HCID 598317553-(1H-Indol-6-yl)-3-(2-methoxy-phenyl)-N-methyl-propionamideHCID 59831909HCID 59831909, compound

Product 1

HCID 59831641HCID 59831641, compound

Procedure

3-(1H-Indol-6-yl)-3-(4-chloro-phenyl)-N-methyl-propionamide XLIV (370 mg, 97%) was prepared from 3-(1H-indol-6-yl)-3-(4-chloro-phenyl)-propionic acid methyl ester following the procedure for 3-(1H-indol-6-yl)-3-(2-methoxy-phenyl)-N-methyl-propionamide XXXVIII (see Example 9).

Sources & evidence

ORD record
ord-a9e730e812dc4ce0ae8db224c7d44bfb
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

Loading…