3-(7-Methoxy-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl ester → 3-(7-Methoxy-1H-Indol-4-yl)-N-methyl-3-phenyl-propionamide

HRID 268789Notes

Reaction equation

HRID 268789 reaction equation
C(O[C:4](=[O:24])[CH2:5][CH:6]([C:13]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]2[C:14]=1[CH:15]=[CH:16][NH:17]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.[NH:25]1C2C(=CC=CC=2C(C2C=CC=CC=2)=CC(NC)=O)C=[CH:26]1>>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:13]([CH:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:5][C:4]([NH:25][CH3:26])=[O:24])=[C:14]2[C:18]=1[NH:17][CH:16]=[CH:15]2

Participants

3

Reactant 2

HCID 598318623-(7-Methoxy-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl esterHCID 691740993-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide

Product 1

HCID 598317653-(7-Methoxy-1H-Indol-4-yl)-N-methyl-3-phenyl-propionamide

Procedure

3-(7-Methoxy-1H-Indol-4-yl)-N-methyl-3-phenyl-propionamide LV was prepared from 3-(7-Methoxy-1H-Indol-4-yl)-3-phenyl-propionic acid ethyl ester using the procedure described for 3-(1H-indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Sources & evidence

ORD record
ord-8cfb041e7db44f649dd5f25614545ad3
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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