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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268800Generated: October 25, 2026

5-Bromo-2-methylindole → 3-(2-Methyl-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl ester

https://huagongshe.com/reaction/268800

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-2-methylindoleHCID 5003968—
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
Product3-(2-Methyl-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355142—

Reaction Steps

3-(2-Methyl-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl ester LXVII (1.25 g, 57%) was prepared from 2-methyl-5-bromoindole using the procedure described above for 3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (see Example 14).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446118B2
Source datasetuspto-grants-2008_11
ORD IDord-c31992fc0bac4f85ad758bc56240606c
Source noteuspto-grants-2008_11