HCID 59831615, compound → HCID 59831837, compound

HRID 268808Notes

Reaction equation

C(O[C:6](=O)[N:7]([CH2:9][CH2:10][CH:11]([C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[N:23]([S:27]([CH3:30])(=[O:29])=[O:28])[CH:22]=[C:21]2[S:31]([CH3:34])(=[O:33])=[O:32])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)C)(C)(C)C.C(OC(=O)N(CCC(C1C=C2C(=CC=1)N(S(C)(=O)=O)C=C2)C1C=CC=CC=1)C)(C)(C)C>>[CH3:30][S:27]([N:23]1[C:24]2[C:20](=[CH:19][C:18]([CH:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:10][CH2:9][NH:7][CH3:6])=[CH:26][CH:25]=2)[C:21]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:22]1)(=[O:28])=[O:29]

Participants

Reactant 2

HCID 59831615HCID 59831615, compound

HCID 59831813HCID 59831813, compound

Product 1

HCID 59831837HCID 59831837, compound

Procedure

[3-(1,3-Bis-methanesulfonyl-1H-indol-5-yl)-3-phenyl-propyl]-methyl-carbamic acid tert-butyl ester LXXVII was deprotected following the same procedure described above for [3-(1-Methanesulfonyl-1H-indol-5-yl)-3-phenyl-propyl]-methyl-carbamic acid tert-butyl ester LXXVI to afford [3-(1,3-Bis-methanesulfonyl-1H-indol-5-yl)-3-phenyl-propyl]-methyl-amine LXXIX as a colorless oil in quantitative yield.

Sources & evidence

ORD record: ord-f357d67bee4b4a6ba7f8f45803502492
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07446118B2

Reaction notes

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