4-bromo-5-methoxy-1H-indole → 6-bromo-7-methoxy-1H-indole

HRID 268825Notes

Reaction equation

HRID 268825 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[O:11][CH3:12].Br[C:14]1C(OC)=CC=C2[C:15]=1C=CN2>>[Br:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]2[C:5]([CH:14]=[CH:15][NH:8]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 220305584-bromo-5-methoxy-1H-indoleHCID 225057131-Bromo-2-methoxy-3-nitrobenzene

Product 1

HCID 598316196-bromo-7-methoxy-1H-indoleYield 14%

Procedure

6-Bromo-7-methoxy-1H-indole CXXXVII (14% yield) was prepared from 2-bromo-6-nitro-anisole using the procedure described above for preparation of 4-bromo-5-methoxyindole XLVI (Example 12).

Sources & evidence

ORD record
ord-d3412b8df1e04e109f4261f98480dbb4
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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