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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268829Generated: October 25, 2026

6-Bromo-1-methyl-1H-indole → 3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

https://huagongshe.com/reaction/268829

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromo-1-methyl-1H-indoleHCID 15546854—
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
Product3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl esterHCID 6735504778%

Reaction Steps

3-(1-Methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester CXLIII (78% yield) was prepared from 6-bromo-1-methyl-1H-indole using the procedure described above for preparation of 3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446118B2
Source datasetuspto-grants-2008_11
ORD IDord-3466369667924574b3d20b0e7873118d
Source noteuspto-grants-2008_11