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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268838Generated: October 25, 2026

3-Pyridineacrylic acid ethyl ester → 3-(1H-Indol-6-yl)-3-pyridin-3-yl-acrylic acid ethyl ester

https://huagongshe.com/reaction/268838

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Pyridineacrylic acid ethyl esterHCID 583337—
Reactant6-BromoindoleHCID 676493—
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
Product3-(1H-Indol-6-yl)-3-pyridin-3-yl-acrylic acid ethyl esterHCID 67355924—

Reaction Steps

3-(1H-Indol-6-yl)-3-pyridin-3-yl-acrylic acid ethyl ester CLVII was prepared from 6-bromo-1H-indole and 3-pyridin-3-yl-acrylic acid ethyl ester using the procedure described above for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446118B2
Source datasetuspto-grants-2008_11
ORD IDord-68fb4e95b7464fc9add72fb075b7ef28
Source noteuspto-grants-2008_11