Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268844Generated: October 26, 2026

3-(3-cyano-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester → 6-(3-Hydroxy-1-pyridin-2-yl-propyl)-1H-indole-3-carbonitrile

https://huagongshe.com/reaction/268844

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3-cyano-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl esterHCID 67356852—
Reactant4-(3-hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrileHCID 67376264—
Product6-(3-Hydroxy-1-pyridin-2-yl-propyl)-1H-indole-3-carbonitrileHCID 67356268—

Reaction Steps

6-(3-Hydroxy-1-pyridin-2-yl-propyl)-1H-indole-3-carbonitrile CLXXII was prepared from 3-(3-cyano-1H-indol-6-yl)-3-pyridin-2-yl-propionic acid ethyl ester using the procedure described for preparation of 4-(3-Hydroxy-1-pheny-propyl)-1H-indole-3-carbonitrile LX (Example 14).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446118B2
Source datasetuspto-grants-2008_11
ORD IDord-8b462bae966f4f58b40381c56312f27e
Source noteuspto-grants-2008_11