6-Bromo-4-methoxy-1H-indole → 3-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-acrylic acid ethyl ester
Reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10](Br)[CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.[CH2:13]([O:15][C:16](=[O:36])[CH:17]=[C:18]([C:25]1[CH:33]=[CH:32][CH:31]=[C:30]2C=1C(C#N)=C[NH:29]2)C1C=CC=CC=1)[CH3:14]>>[CH2:13]([O:15][C:16](=[O:36])[CH:17]=[C:18]([C:10]1[CH:9]=[C:8]2[C:4]([CH:5]=[CH:6][NH:7]2)=[C:3]([O:2][CH3:1])[CH:11]=1)[C:25]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1)[CH3:14]Participants
3
Procedure
3-(4-Methoxy-1H-indol-6-yl)-3-pyridin-2-yl-acrylic acid ethyl ester CLXXIV was prepared from 4-methoxy-6-bromo-1H-indole and 3-pyridin-2-yl-acrylic acid ethyl este using the procedure described for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).
Sources & evidence
- ORD record
- ord-67f458b82586437e9823b01fdd0d8ade
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07446118B2
Reaction notes
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