3-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamide → 3-(5-Methoxy-1H-indol-7-yl)-3-phenyl-propionic acid ethyl ester

HRID 268850Notes

Reaction equation

HRID 268850 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH:5]=[C:6]([C:13]1[CH:14]=[C:15]([O:22][CH3:23])[CH:16]=[C:17]2[C:21]=1[NH:20][CH:19]=[CH:18]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].N1C2C(=CC=CC=2C(C2C=CC=CC=2)CC(NC)=O)C=C1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][CH:6]([C:13]1[CH:14]=[C:15]([O:22][CH3:23])[CH:16]=[C:17]2[C:21]=1[NH:20][CH:19]=[CH:18]2)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 598317453-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamideHCID 673565993-(5-Methoxy-1H-indol-7-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 598319183-(5-Methoxy-1H-indol-7-yl)-3-phenyl-propionic acid ethyl ester

Procedure

3-(5-Methoxy-1H-indol-7-yl)-3-phenyl-propionic acid ethyl ester CLXXX was prepared from 3-(5-methoxy-1H-indol-7-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-propionamide XIX (Example 4).

Sources & evidence

ORD record
ord-78a35fac3d8f4e699a5bc1219a86acf8
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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