3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(1H-Indazol-4-yl)-N-methyl-3-phenyl-acrylamide

HRID 268857Notes

Reaction equation

HRID 268857 reaction equation
C([O:3][C:4](=O)[CH:5]=[C:6]([C:13]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:14]=1[CH:15]=[N:16][NH:17]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(OC(=O)C=C(C1C=CC=C2C=1C(C#N)=[CH:38][NH:39]2)C1C=CC=CC=1)C>>[NH:17]1[C:18]2[C:14](=[C:13]([C:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[CH:5][C:4]([NH:39][CH3:38])=[O:3])[CH:21]=[CH:20][CH:19]=2)[CH:15]=[N:16]1

Participants

3

Reactant 2

HCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355567HCID 67355567, compound

Product 1

HCID 673567373-(1H-Indazol-4-yl)-N-methyl-3-phenyl-acrylamide

Procedure

3-(1H-Indazol-4-yl)-N-methyl-3-phenyl-acrylamide CXCII was prepared from 3-(1H-indazol-4-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Sources & evidence

ORD record
ord-d0172fcf0a814833ae50479c59e00da9
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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