3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → HCID 67355673, compound

HRID 268862Notes

Reaction equation

HRID 268862 reaction equation
C([O:3][C:4](=O)[CH:5]=[C:6]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][N:17]=[CH:16]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(OC(=O)C=C(C1C=CC=C2C=1C(C#N)=[CH:38][NH:39]2)C1C=CC=CC=1)C>>[NH:18]1[C:19]2[C:15](=[CH:14][C:13]([C:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[CH:5][C:4]([NH:39][CH3:38])=[O:3])=[CH:21][CH:20]=2)[CH:16]=[N:17]1

Participants

3

Reactant 2

HCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355759HCID 67355759, compound

Product 1

HCID 67355673HCID 67355673, compound

Procedure

3-(1H-Indazol-5-yl)-N-methyl 3-phenyl-acrylamide CCIV was prepared from 3-(1H-indazol-5-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Sources & evidence

ORD record
ord-f481f6e7cc234cb88fdeb58be6256bcd
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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