3-(7-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → HCID 178470869, compound

HRID 268870Notes

Reaction equation

HRID 268870 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[Cl:11].[CH2:12]([O:14][C:15](=[O:35])[CH:16]=[C:17](C1C=CC(OC)=C2C=1C=CN2)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:35])[CH:16]=[C:17]([C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[Cl:11])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:13]

Participants

3

Reactant 2

HCID 673560833-(7-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 178478419HCID 178478419, compound

Product 1

HCID 178470869HCID 178470869, compound

Procedure

3-(3-Chloro-1H-indazol-5-yl)-3-phenyl-acrylic acid ethyl ester CCXV was prepared from 5-bromo-3-chloro-1H-indazole using the procedure described for preparation of 3-(7-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LIII (Example 13).

Sources & evidence

ORD record
ord-499cd44cea424dc29ab070aa44f31871
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

Loading…