HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-methyl-1-propanol → 5-chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiophene-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | 5-Chlorothiophene-2-sulfonyl chloride | HCID 2733925 | — |
| Product | 5-chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiophene-2-sulfonamide | HCID 22500823 | 77.2% |
Reaction Steps
Prepared by general procedure III from commercially available 5-chloro-thiophene-2-sulfonyl chloride (1.0 g, 4.61 mmol) and 2-amino-2-methyl-1-propanol (1.23 g, 13.8 mmol) to give the title compound (0.96 g, 77%) as a white solid. MS (ISN) 268.1 [(M−H)−], mp 112° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446113B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-dfa2a781c67946b49446be8f8c5adf3e |
| Source note | uspto-grants-2008_11 |