HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl difluoroacetate → 4,4-Difluoro-1-(4-trifluoromethylphenyl)butane-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl difluoroacetate | HCID 9961 | — |
| Reactant | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| Product | 4,4-Difluoro-1-(4-trifluoromethylphenyl)butane-1,3-dione | HCID 18920369 | 101.4% |
Reaction Steps
Prepared from commercially available ethyl difluoroacetate (14.49 g, 117 mmol) and commercially available 4-(trifluoromethyl)acetophenone (15.36 g, 80 mmol) as described in example C.1 step 1 to give 4,4-difluoro-1-(4-trifluoromethyl-phenyl)-butane-1,3-dione (21.60 g, 101%) as a light brown oil. MS (ISN) 265.0 [(M−H)−].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446113B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-1071a90aa6044f4f8cebe54e06bd3dcc |
| Source note | uspto-grants-2008_11 |