Sulfuric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid n-butyl ester

HRID 26903Notes

Reaction equation

HRID 26903 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:20])[CH2:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1.OS(O)(=O)=O>C(O)CCC>[CH2:7]([O:18][C:17](=[O:19])[CH2:16][CH:15]([C:12]1[CH:13]=[CH:14][C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[CH:10][CH:11]=1)[CH3:20])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

Product 1

HCID 537186413-(2',4'-Difluoro-4-biphenylyl)butyric acid n-butyl ester

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

2 g. of 3-(2',4'-difluoro-4-biphenylyl)butyric acid are heated under reflux with 1 ml. of concentrated H2SO4 and 30 ml. of n-butanol for 7 hours. The mixture is evaporated and taken up in chloroform and the chloroform solution is washed with NaHCO3 solution, dried and evaporated to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid n-butyl ester.

Workup

  1. temperatureunder reflux with 1 ml
  2. customThe mixture is evaporated
  3. washthe chloroform solution is washed with NaHCO3 solution
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-0e264ee8ca3242d0adeab9a219e5a94e
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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