Iodine chloride → HCID 67000884, compound

HRID 269052Notes

Reaction equation

[CH:1]1([C:4]2[C:5]3[N:6]([CH:20]=[CH:21][N:22]=3)[CH:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=3)[CH:9]=2)[CH2:3][CH2:2]1.[I:23]Cl>>[CH:1]1([C:4]2[C:5]3[N:6]([C:20]([I:23])=[CH:21][N:22]=3)[CH:7]=[C:8]([C:10]3[CH:11]=[CH:12][C:13]([C:16]([F:18])([F:17])[F:19])=[CH:14][CH:15]=3)[CH:9]=2)[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 24640Iodine chloride

HCID 67000912HCID 67000912, compound

Product 1

HCID 67000884HCID 67000884, compoundYield 99%

Procedure

Prepared from 8-cyclopropyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine (example C.25 step 4) (2.2 g, 7 mmol) and iodine monochloride as described in example C.20 step 3. Obtained the title compound as a grey solid (3.1 g, 99%). MS (ISP) 429.2 [(M+H)+].

Sources & evidence

ORD record: ord-c3e40269b0184e0f943438fd5fa4f2fe
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07446113B2

Reaction notes

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