Thionyl Chloride → 3-(2',4'-Difluoro-4-biphenylyl)butyryl chloride

HRID 26907Notes

Reaction equation

HRID 26907 reaction equation
S(Cl)([Cl:3])=O.[F:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[C:13]1[CH:18]=[CH:17][C:16]([CH:19]([CH3:24])[CH2:20][C:21](O)=[O:22])=[CH:15][CH:14]=1>C1C=CC=CC=1>[F:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[C:13]1[CH:18]=[CH:17][C:16]([CH:19]([CH3:24])[CH2:20][C:21]([Cl:3])=[O:22])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

Product 1

HCID 213226013-(2',4'-Difluoro-4-biphenylyl)butyryl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

6 g. of thionyl chloride and 10 g. of 3-(2',4'-difluoro-4-biphenylyl)butyric acid in 80 ml. of benzene are allowed to stand at 25° for 24 hours and the mixture is evaporated under reduced pressure to give 3-(2',4'-difluoro-4-biphenylyl)butyryl chloride.

Workup

  1. customthe mixture is evaporated under reduced pressure

Sources & evidence

ORD record
ord-691834c7f4784567b81a9548083e2b75
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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