HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilylacetylene → 5-[(Trimethylsilyl)ethynyl]pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 2-Amino-5-iodopyrimidine | HCID 241102 | — |
| Product | 5-[(Trimethylsilyl)ethynyl]pyrimidin-2-amine | HCID 67001117 | 73% |
Reaction Steps
Prepared from commercially available 2-amino-5-iodopyrimidine (60 g, 271 mmol) and trimethylsilylacetylene (49 mL, 354 mmol) as described in example D.1 method 1 step 1. Obtained the title compound as a light brown solid (37.66 g, 73%). MS (ISP) 192 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446113B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-58665d97df52442d98cf369b4f1ff7db |
| Source note | uspto-grants-2008_11 |