3-Ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine → HCID 11852212, compound

HRID 269092Notes

Reaction equation

HRID 269092 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:9]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)=[N:8][C:7]=12)#[CH:2].[CH:26]1([C:29]2[C:34](OS(C(F)(F)F)(=O)=O)=[CH:33][CH:32]=[CH:31][N:30]=2)[CH2:28][CH2:27]1>>[CH:26]1([C:29]2[C:34]([C:2]#[C:1][C:3]3[CH:4]=[N:5][N:6]4[C:11]([C:12]([F:14])([F:13])[F:15])=[CH:10][C:9]([C:16]5[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=5)=[N:8][C:7]=34)=[CH:33][CH:32]=[CH:31][N:30]=2)[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 715397323-Ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidineHCID 86608030HCID 86608030, compound

Product 1

HCID 11852212HCID 11852212, compound

Procedure

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.1) (355 mg, 1.0 mmol) and trifluoro-methanesulfonic acid 2-cyclopropyl-pyridin-3-yl ester (Example B.10) (294 mg, 1.3 mmol) according to general procedure II. Obtained as a yellow solid (220 mg, 46%). MS (ISP) 473.3 [(M+H)+]; mp 202° C.

Sources & evidence

ORD record
ord-c54e4db4e5a44ae6bc81aec923ac7951
Source dataset
uspto-grants-2008_11
Patent number
US07446113B2

Reaction notes

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