HRID269127

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID61052651

未命名化合物

结构：C#Cc1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)c(OCC)c3)nc12

HCID86608040

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(-c2cc(C(F)(F)F)n3ncc(C#Cc4ncc(S(=O)(=O)NC(C)(C)CO)s4)c3n2)ccc1C(F)(F)F

HCID86608039

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 5-(3-Ethoxy-4-trifluoromethyl-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine (example C.3) (400 mg, 1.0 mmol) and 2-chloro-thiazole-5-sulfonic acid(2-hydroxy-1,1-dimethyl-ethyl)-amide (example B.14) (244 mg, 1.0 mmol) according to general procedure II. Obtained as an orange solid (80 mg, 12%). MS (ISP) 634.1 [(M+H)+]; mp 209-211° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-870b6be094cf414fba7dc9e3e894c92e
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07446113B2
来源说明: uspto-grants-2008_11

反应 SMILES

[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]3[N:24]=[CH:25][C:26]([C:27]#[CH:28])=[C:16]3[N:15]=2)[CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH3:2].[OH:29][CH2:30][C:31]([NH:34][S:35]([C:38]1[S:42][C:41](Cl)=[N:40][CH:39]=1)(=[O:37])=[O:36])([CH3:33])[CH3:32]>>[OH:29][CH2:30][C:31]([NH:34][S:35]([C:38]1[S:42][C:41]([C:28]#[C:27][C:26]2[CH:25]=[N:24][N:17]3[C:18]([C:20]([F:21])([F:22])[F:23])=[CH:19][C:14]([C:6]4[CH:7]=[CH:8][C:9]([C:10]([F:13])([F:11])[F:12])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=4)=[N:15][C:16]=23)=[N:40][CH:39]=1)(=[O:37])=[O:36])([CH3:33])[CH3:32]