3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid

HRID 26915Notes

Reaction equation

HRID 26915 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](O)([CH3:20])[CH2:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1>[Pd].C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:20])[CH2:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 213225833-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid

Product 1

HCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 3.18 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid in 30 ml. of acetic acid is hydrogenated, at 20° and under normal pressure, on 0.2 g. of 10% Pd/C in the presence of 0.01 ml. of HClO4. The mixture is filtered and the filtrate is diluted with water to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

Workup

  1. customis hydrogenated, at 20° and under normal pressure, on 0.2 g
  2. filtrationThe mixture is filtered
  3. additionthe filtrate is diluted with water

Sources & evidence

ORD record
ord-ad5170dffb0b45ce8aed5b1699c7ca22
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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