HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid ethyl ester | HCID 54340187 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid | HCID 21322540 | — |
Reaction Steps
3.04 g. of 3-(2',4'-difluoro-4-biphenylyl)butyric acid ethyl ester and 1 g. of KOH in 25 ml. of ethanol are heated under reflux for 2 hours. The mixture is evaporated. The residue is dissolved in water and the solution is washed with ether and acidified to pH 3 with hydrochloric acid and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)-butyric acid, m.p. 109°-110°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04151302 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-fd7c072f0dec444dbff8c818a69ad971 |
| Source note | uspto-grants-1979_04 |